Endocrine Abstracts

Background: The insulin tolerance test (ITT) is considered the gold standard test for evaluating the ACTH–cortisol axis in patients with pituitary disease. However, the test requires time and personnel resources, and has clear contraindications. Therefore, an ACTH stimulation test is often performed instead.Objective: The objective was to compare the cortisol response acquired by ACTH stimulation and during ITT in patients with pituitary disease.</p...

Introduction: Postpartum necrosis of the anterior pituitary gland is well-described, but antepartum pituitary insufficiency (API) is reported only in a few women with type 1 diabetes (T1D). API has an abrupt onset and may have fatal outcome.Case report: A 36-year-old woman with T1D and laser-treated retinopathy became pregnant after repeated IVF. In gestational week (GW) 10, she used insulin 34–42 U/day, HbA1c was 6.2% and cortisol (0800 h)...

Objective: Early postoperative results for the Preoperative Octreotide Treatment of Acromegaly (POTA) study has been published, and like later randomized studies we demonstrated a beneficial effect of presurgical treatment with somatostatin analogues (SSA) in GH-secreting macroadenomas when evaluated 3–4 months postoperatively. However, concerns about a potential lingering effect of SSA and thereby potential false positive results have been raised. The objective of this s...